Drug–drug interactions of Z-338, a novel gastroprokinetic agent, with terfenadine, comparison with cisapride, and involvement of UGT1A9 and 1A8 in the human metabolism of Z-338

• Published in: European journal of pharmacology Vol. 497; no. 2; pp. 223 - 231
• Main Authors: Furuta, Shigeru, Kamada, Emiko, Omata, Takeshi, Sugimoto, Tohru, Kawabata, Yoshihiro, Yonezawa, Keiko, Wu, Xiaochun Cheryl, Kurimoto, Tadashi
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 23.08.2004; Elsevier
• Subjects: Benzamides - metabolism; Biological and medical sciences; Cell Line; Cisapride; Cisapride - metabolism; CYP inhibition; Dose-Response Relationship, Drug; Drug Interactions - physiology; Gastrointestinal Agents - metabolism; Glucuronosyltransferase - metabolism; hERG; Humans; Male; Medical sciences; Microsomes, Liver - drug effects; Microsomes, Liver - enzymology; Pharmacology. Drug treatments; Terfenadine; Terfenadine - metabolism; Thiazoles - metabolism; Z-338; Terfenadine; Cisapride; hERG; Z-338; CYP inhibition; Human; Metabolism; Antihistaminic; Benzamide derivatives; Drug interaction; Antagonist; H1 Histamine receptor; Antiemetic; Comparative study

In the present study, the inhibitory properties of N-[2-(diisopropylamino)ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxamide monohydrochloride trihydrate (Z-338), a novel gastroprokinetic agent, were investigated and compared with those of cisapride to establish its potentia...