Assessment of growth inhibition and morphological changes in in vitro and in vivo hepatocellular carcinoma models post treatment with dl1520 adenovirus

• Published in: Cancer gene therapy Vol. 9; no. 5; pp. 414 - 420
• Main Authors: Habib, Nagy A, Mitry, Ragai R, Sarraf, Catherine E, Jiao, Long R, Havlík, Roman, Nicholls, Joanna, Jensen, Steen L
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.05.2002
• Subjects: Adenoviridae - genetics; Animals; Carcinoma, Hepatocellular - pathology; Cell culture; Cell Division; Cell growth; Cell Survival; Clinical trials; Gene Deletion; Genes, p53; Genetic Therapy - methods; Hepatocellular carcinoma; Humans; Immunoblotting; Liver cancer; Liver Neoplasms - therapy; Liver Neoplasms, Experimental - therapy; Mice; Mice, SCID; Microscopy, Electron; Morphology; Mutants; Mutation; Neoplasm Transplantation; Physical characteristics; Polymerase chain reaction; Time Factors; Transmission electron microscopy; Tumor Cells, Cultured; Xenografts

E1B-deleted virus dl1520 (ONYX-015) has been previously used in clinical trials mainly for treatment of head and neck tumors, and has been shown to have beneficial effects independent of p53 status. The main aim of this investigation was to carry out a preclinical study for assessment of the use of...