Alpha-Tocopherol Supplementation in Healthy Individuals Reduces Low-Density Lipoprotein Oxidation but Not Atherosclerosis The Vitamin E Atherosclerosis Prevention Study (VEAPS)

• Published in: Circulation (New York, N.Y.) Vol. 106; no. 12; pp. 1453 - 1459
• Main Authors: Hodis, Howard N., Mack, Wendy J., LaBree, Laurie, Mahrer, Peter R., Sevanian, Alex, Liu, Chao-ran, Liu, Ci-hua, Hwang, Juliana, Selzer, Robert H., Azen, Stanley P.
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 17.09.2002
• Subjects: Adult; Aged; alpha-Tocopherol - administration & dosage; alpha-Tocopherol - therapeutic use; Antioxidants - administration & dosage; Antioxidants - therapeutic use; Arteriosclerosis - blood; Arteriosclerosis - diagnostic imaging; Arteriosclerosis - prevention & control; Biological and medical sciences; Carotid Artery, Common - diagnostic imaging; Dietary Supplements; Disease Progression; Female; General and cellular metabolism. Vitamins; Humans; Lipoproteins, LDL - blood; Male; Medical sciences; Middle Aged; Patient Compliance; Pharmacology. Drug treatments; Tunica Intima - diagnostic imaging; Tunica Media - diagnostic imaging; Ultrasonography; Human; Prognosis; Cardiovascular disease; Cholesterol LDL; Controlled therapeutic trial; E-Vitamins; Antioxidant; Vascular disease; Lipoprotein LDL; Chemotherapy; Treatment; Atherosclerosis; Oxidation; Tocopherol

Background— Epidemiological studies have demonstrated an inverse relationship between vitamin E intake and cardiovascular disease (CVD) risk. In contrast, randomized controlled trials have reported conflicting results as to whether vitamin E supplementation reduces atherosclerosis progression and CV...