Stroke volume and sympathetic responses to lower-body negative pressure reveal new insight into circulatory shock in humans

• Published in: Autonomic neuroscience Vol. 111; no. 2; pp. 127 - 134
• Main Authors: Convertino, Victor A, Ludwig, David A, Cooke, William H
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 30.04.2004; Elsevier
• Subjects: Adult; Autonomic regulation; Biological and medical sciences; Central hypovolemia; Fundamental and applied biological sciences. Psychology; Humans; Lower Body Negative Pressure; Male; Medical sciences; Microneurography; Muscle, Skeletal - innervation; Neurology; Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ; Shock - physiopathology; Stroke Volume - physiology; Sympathetic Nervous System - physiology; Vascular diseases and vascular malformations of the nervous system; Vertebrates: nervous system and sense organs; Central hypovolemia; Microneurography; Autonomic regulation; Shock; Human; Nervous system diseases; Stroke; Cardiovascular disease; Sympathetic nervous system; Cerebral disorder; Vascular disease; Autonomic nervous system; Central nervous system disease; Cerebrovascular disease

We measured various hemodynamic responses and muscle sympathetic nerve activity (MSNA) in human subjects during a graded lower-body negative pressure (LBNP) protocol to test the hypotheses that: (1) reduced stroke volume (SV) is linearly related to increased MSNA; and (2) the onset of symptoms of im...