Physical Inactivity, Obesity, and Type 2 Diabetes: An Evolutionary Perspective

• Published in: Research quarterly for exercise and sport Vol. 88; no. 1; pp. 1 - 8
• Main Authors: Eaton, S. Boyd, Eaton, Stanley B.
• Format: Journal Article
• Language: English
• Published: United States Routledge 02.01.2017
• Subjects: Adipocytes - metabolism; Adipose Tissue - metabolism; Animals; Biochemistry; Blood Glucose - metabolism; Body Composition; Diabetes; Diabetes Mellitus, Type 2 - etiology; Diabetes Mellitus, Type 2 - prevention & control; Diabetes Mellitus, Type 2 - therapy; Drug Therapy; Exercise; fat-muscle index (FMI); Health Promotion; Human Body; Humans; Hyperinsulinism - complications; insulin resistance; Insulin Resistance - physiology; Life Style; Muscle Cells - metabolism; Obesity; Obesity - complications; Physical Activity Level; Prevention; Receptor, Insulin - metabolism; Sedentary Lifestyle; fat-muscle index (FMI); exercise; insulin resistance; Body composition

Physical inactivity (and unhealthy nutrition) has distorted body composition and, in turn, reordered the proportions of myocyte and adipocyte insulin receptors. Insulin acting on adipocyte receptors produces less glucose uptake than does comparable interaction with myocyte receptors. Accordingly, in...