Cortical neurons selectively inhibit MHC class II induction in astrocytes but not in microglial cells

• Published in: International immunology Vol. 5; no. 3; p. 249
• Main Authors: Tontsch, U, Rott, O
• Format: Journal Article
• Language: English
• Published: England 01.03.1993
• Subjects: Animals; Antigen-Presenting Cells - immunology; Astrocytes - immunology; Cells, Cultured; Cerebral Cortex - cytology; Cerebral Cortex - immunology; Down-Regulation; Histocompatibility Antigens Class II - biosynthesis; Lymphocyte Activation; Neuroglia - immunology; Neurons - immunology; Rats; T-Lymphocytes - immunology

Astrocytes have been shown to act as potent accessory cells for MHC class II-restricted T cell responses in vitro after treatment with interferon-gamma. In contrast, even under conditions of severe central nervous system (CNS) inflammation, they seem to express little, if any, class II molecules in...