The Lymphotoxin-β Receptor Is Necessary and Sufficient for LIGHT-mediated Apoptosis of Tumor Cells

• Published in: The Journal of biological chemistry Vol. 275; no. 19; pp. 14307 - 14315
• Main Authors: Rooney, Isabelle A., Butrovich, Kris D., Glass, Alison A., Borboroglu, Stephen, Benedict, Chris A., Whitbeck, J.Charles, Cohen, Gary H., Eisenberg, Roselyn J., Ware, Carl F.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 12.05.2000
• Subjects: Amino Acid Sequence; Apoptosis - physiology; Base Sequence; DNA Primers; Humans; Integrins - biosynthesis; Lymphotoxin beta Receptor; Molecular Sequence Data; Precipitin Tests; Proteins - metabolism; Receptors, Tumor Necrosis Factor - chemistry; Receptors, Tumor Necrosis Factor - physiology; Recombinant Proteins - metabolism; Sequence Homology, Amino Acid; Signal Transduction; Surface Plasmon Resonance; TNF Receptor-Associated Factor 3; Tumor Cells, Cultured

LIGHT is a tumor necrosis factor (TNF) ligand superfamily member, which binds two known cellular receptors, lymphotoxin-β receptor (LTβR) and the herpesvirus entry mediator (HveA). LIGHT is a homotrimer that activates proapoptotic and integrin-inducing pathways. Receptor binding residues via LIGHT w...