Limbic-predominant age-related TDP-43 encephalopathy in the oldest old: a population-based study

• Published in: Brain (London, England : 1878) Vol. 148; no. 1; pp. 154 - 167
• Main Authors: Mikhailenko, Elizaveta, Colangelo, Kia, Tuimala, Jarno, Kero, Mia, Savola, Sara, Raunio, Anna, Kok, Eloise H, Tanskanen, Maarit, Mäkelä, Mira, Puttonen, Henri, Mäyränpää, Mikko I, Kumar, Darshan, Kaivola, Karri, Paetau, Anders, Tienari, Pentti J, Polvikoski, Tuomo, Myllykangas, Liisa
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 07.01.2025
• Subjects: Aged, 80 and over; Aging - pathology; Arteriolosclerosis - pathology; Cohort Studies; Dementia; DNA-Binding Proteins - metabolism; Female; Finland - epidemiology; Humans; Limbic System - pathology; Male; Original; TDP-43 Proteinopathies - epidemiology; TDP-43 Proteinopathies - pathology; Finland; neurodegeneration; very old; autopsy; multivariate analysis; neuropathology; mixed pathology

Population-based cohort studies are essential for understanding the pathological basis of dementia in older populations. Previous studies have shown that limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) increases with age, but there have been only a few studies,...