Behavioral alterations produced by chronic naloxone injections
Repeated blockade of the endorphin receptors eventually induces symptoms resembling an opiate abstinence syndrome, despite the complete absence of opiate narcotics. Rats were injected with 0.6 mg/kg naloxone or with injection vehicle alone twice a day for six days. They were observed twice a day for...
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| Published in | Pharmacology, biochemistry and behavior Vol. 17; no. 3; pp. 389 - 392 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
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United States
Elsevier Inc
01.01.1982
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| Abstract | Repeated blockade of the endorphin receptors eventually induces symptoms resembling an opiate abstinence syndrome, despite the complete absence of opiate narcotics. Rats were injected with 0.6 mg/kg naloxone or with injection vehicle alone twice a day for six days. They were observed twice a day for four subsequent days. Body shakes, head shakes, scratches and total symptoms were significantly elevated in the naloxone treated group over controls. Symptoms were completely reversed by a small dose of morphine but not by naloxone. In a second experiment, rats were injected for ten days with the same dosage of naloxone. The abstinence-like syndrome began after six days of naloxone and continued for several days after cessation of injections. Total symptoms, body shakes, scratches and aggression were significantly elevated over controls and were reversed by morphine but not by naloxone. |
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| AbstractList | Repeated blockade of the endorphin receptors eventually induces symptoms resembling an opiate abstinence syndrome, despite the complete absence of opiate narcotics. Rats were injected with 0.6 mg/kg naloxone or with injection vehicle alone twice a day for six days. They were observed twice a day for four subsequent days. Body shakes, head shakes, scratches and total symptoms were significantly elevated in the naloxone treated group over controls. Symptoms were completely reversed by a small dose of morphine but not by naloxone. In a second experiment, rats were injected for ten days with the same dosage of naloxone. The abstinence-like syndrome began after six days of naloxone and continued for several days after cessation of injections. Total symptoms, body shakes, scratches and aggression were significantly elevated over controls and were reversed by morphine but not by naloxone. Repeated blockade of the endorphin receptors eventually induces symptoms resembling an opiate abstinence syndrome, despite the complete absence of opiate narcotics. Rats were injected with 0.6 mg/kg naloxone or with injection vehicle alone twice a day for six days. They were observed twice a day for four subsequent days. Body shakes, hear shakes, scratches and total symptoms were significantly elevated in the naloxone treated group over controls. Symptoms were completely reversed by a small dose of morphine but not by naloxone. In a second experiments, rats were injected for ten days with the same dosage of naloxone. The abstinence-like syndrome began six days of naloxone and continued for several days after cessation of injections. Total symptoms, body shakes, scratches and aggression were significantly elevated over controls and were reversed by morphine but not by naloxone. |
| Author | Malin, David H. Hood, Joyce L. Swank, Paul Layng, Michael P. Baker, Melanie J. |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/6890681$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1126/science.715455 10.1126/science.432642 10.1016/0024-3205(76)90339-8 10.1016/0306-4530(77)90026-9 10.1007/BF00426478 10.1038/263783a0 10.1016/0091-3057(78)90167-3 10.1016/0028-3908(76)90037-X 10.1016/0024-3205(79)90237-6 10.1016/0024-3205(78)90179-0 10.1037/h0077609 10.1016/0024-3205(79)90403-X 10.1016/0091-3057(78)90264-2 10.1016/0024-3205(79)90066-3 10.1126/science.561998 10.1016/0361-9230(77)90014-4 10.1016/0024-3205(75)90043-0 10.1126/science.343250 10.1159/000122889 10.1016/0024-3205(77)90264-8 10.1016/0014-2999(77)90235-7 |
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| Keywords | Endorphins Morphine Opiates Naloxone Abstinence syndrome Dependence |
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Behav. doi: 10.1016/0091-3057(78)90167-3 contributor: fullname: Herman – volume: 15 start-page: 683 year: 1976 ident: 10.1016/0091-3057(82)90293-3_BIB24 article-title: Antinociceptive activity of narcotic antagonists and partial agonists analgesics and other agents in the tail immersion test in mice and rats publication-title: Neuropharmacology doi: 10.1016/0028-3908(76)90037-X contributor: fullname: Sewell – volume: 24 start-page: 1861 year: 1979 ident: 10.1016/0091-3057(82)90293-3_BIB29 article-title: Diurnal differences in opioid peptide levels correlated with nociceptive specificity publication-title: Life Sci. doi: 10.1016/0024-3205(79)90237-6 contributor: fullname: Wesche – volume: 23 start-page: 2525 year: 1978 ident: 10.1016/0091-3057(82)90293-3_BIB3 article-title: Involvement of endorphins in emotional hyperthermia of rats publication-title: Life Sci. doi: 10.1016/0024-3205(78)90179-0 contributor: fullname: Blasig – volume: 93 start-page: 736 year: 1979 ident: 10.1016/0091-3057(82)90293-3_BIB7 article-title: Naloxone and shock-elicited freezing in the rat publication-title: J. comp. physiol. 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| SubjectTerms | Abstinence syndrome Animals Behavior, Animal - drug effects Dependence Endorphins Humans Injections, Intravenous Male Morphine Morphine - pharmacology Morphine Dependence - psychology Naloxone Naloxone - pharmacology Opiates Rats Rats, Inbred Strains Substance Withdrawal Syndrome - psychology |
| Title | Behavioral alterations produced by chronic naloxone injections |
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