A Pilot Study To Assess the Suitability of Riboflavin As a Surrogate Marker of Breast Cancer Resistance Protein in Healthy Participants - Shen, Hong; Huo, Runlan; Zhang, Yueping; Wang, Linna; Tong, Nian; Chen, Weiqi; Paris, Andrew J.; Mensah, Kofi; Chen, Min; Xue, Yongjun; Li, Wenying; Sinz, Michael (The Journal of pharmacology and experimental therapeutics, 2024)
Keywords: Adult; ATP Binding Cassette Transporter, Subfamily G, Member 2 - antagonists & inhibitors; ATP Binding Cassette Transporter, Subfamily G, Member 2 - metabolism; Biomarkers - blood; Biomarkers - metabolism; Healthy Volunteers; Humans; Male; Methotrexate - blood; Methotrexate - metabolism; Methotrexate - pharmacokinetics; Methotrexate - pharmacology; Middle Aged; Neoplasm Proteins - antagonists & inhibitors; Neoplasm Proteins - metabolism; Pilot Projects; Riboflavin - blood; Riboflavin - metabolism; Riboflavin - pharmacokinetics; Young Adult; OCT; FDA; LLC-PK1; OAT; E3S; Cmax,u; DDI; Cmax,inlet,u; AUC; MTX; eV; LC-MS/MS; QC; EMA; CCK-8; m/z; MDR; AUC(0–24h); HPLC; BCRP; E17βG; P-gp; CI; MATE; PYR; IR; OATP; ER; GMR; RIF; HEK; PROB; PAH; Tmax; AUC(0–4h); NER; HBSS; SSZ; AUCR; Igut