Transcription Factors Controlling Primary and Secondary Metabolism in Filamentous Fungi: The β-Lactam Paradigm

• Published in: Fermentation (Basel) Vol. 4; no. 2; p. 47
• Main Authors: García-Estrada, Carlos, Domínguez-Santos, Rebeca, Kosalková, Katarina, Martín, Juan-Francisco
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.06.2018
• Subjects: Antibiotics; Biosynthesis; Cell cycle; control of gene expression; filamentous fungi; Fungi; Gene clusters; Gene expression; Heterochromatin; Metabolism; Metabolites; Penicillin; Pharmaceutical industry; Physiology; regulation; Regulatory proteins; secondary metabolism; Secondary metabolites; Signal transduction; Sporulation; Transcription factors; Zinc finger proteins; β-Lactam antibiotics; Spain

Transcription factors are key regulatory proteins in all living beings. In fungi, transcription factors include either broad-domain regulatory proteins that affect the expression of many genes involved in biosynthetic processes, or proteins encoded by cluster-associated (also called pathway-specific...