Glucagon-Like Peptide 1 Receptor Agonist Stimulation Inhibits Laser-Induced Choroidal Neovascularization by Suppressing Intraocular Inflammation

• Published in: Investigative ophthalmology & visual science Vol. 66; no. 5; p. 15
• Main Authors: Machida, Akira, Suzuki, Keiji, Nakayama, Takafumi, Miyagi, Sugao, Maekawa, Yuki, Murakami, Ryuya, Uematsu, Masafumi, Kitaoka, Takashi, Oishi, Akio
• Format: Journal Article
• Language: English
• Published: United States The Association for Research in Vision and Ophthalmology 01.05.2025
• Subjects: Animals; Choroidal Neovascularization - drug therapy; Choroidal Neovascularization - etiology; Choroidal Neovascularization - metabolism; Choroidal Neovascularization - prevention & control; Cytokines - metabolism; Disease Models, Animal; Glucagon-Like Peptide-1 Receptor - metabolism; Glucagon-Like Peptide-1 Receptor Agonists; Immunohistochemistry; Inflammation - metabolism; Inflammation - prevention & control; Intravitreal Injections; Laser Coagulation - adverse effects; Liraglutide - pharmacology; Liraglutide - therapeutic use; Male; Mice; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein - metabolism; Real-Time Polymerase Chain Reaction; Retina

The glucagon-like peptide-1 receptor (GLP-1R), a diabetes therapy target, is expressed in multiple organs and is associated with neuroprotective, anti-inflammatory, and antitumor effects, particularly in cardiac and cerebral tissues. Although GLP-1's role in diabetic and ischemic retinopathies...