Selective oxidation of active site aromatic residues in engineered Cu proteins

• Published in: Chemical science (Cambridge) Vol. 16; no. 1; pp. 98 - 13
• Main Authors: Uyeda, Kylie S, Follmer, Alec H, Borovik, A. S
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 18.12.2024; The Royal Society of Chemistry
• Subjects: Biotin; Chemistry; Coordination; Copper; Hydrogen bonds; Hydrogen peroxide; Oxidation; Oxidizing agents; Polysaccharides; Residues; Tyrosine

Recent studies have revealed critical roles for the local environments surrounding metallocofactors, such as the newly identified Cu D site in particulate methane monooxygenases (pMMOs) and the second sphere aromatic residues in lytic polysaccharide monooxygenases (LPMOs), implicated in the protecti...