Determination of warfarin at trace-levels in water by solid-phase spectrofluorimetry

A new selective and sensitive spectrofluorimetric method for the determination of warfarin at trace levels (0.2-50.0 ng/ml) in water is proposed. Warfarin is fixed on Sephadex QAE A-25 gel (at pH = 7.0) and its fluorescence is measured directly in the solid-phase using a 1-mm silica cell at 312/385...

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Published inAnalytical and bioanalytical chemistry Vol. 354; no. 4; pp. 470 - 473
Main Authors Quero, J L, Rohand, J, Montón, A N, Castañeda, R A, Capitán-Vallvey, L F
Format Journal Article
LanguageEnglish
Published Germany 01.02.1996
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Summary:A new selective and sensitive spectrofluorimetric method for the determination of warfarin at trace levels (0.2-50.0 ng/ml) in water is proposed. Warfarin is fixed on Sephadex QAE A-25 gel (at pH = 7.0) and its fluorescence is measured directly in the solid-phase using a 1-mm silica cell at 312/385 nm with a detection/quantification limit of 0.06/0.2 ng/ml, a relative standard deviation of 2.3% and recoveries between 95 and 105%. The method is applied to the determination of warfarin residues in water.
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ISSN:1618-2642
1618-2650
DOI:10.1007/s0021663540470