Homeotic factor ATBF1 induces the cell cycle arrest associated with neuronal differentiation

• Published in: Development (Cambridge) Vol. 132; no. 23; pp. 5137 - 5145
• Main Authors: Jung, Cha-Gyun, Kim, Hye-Jung, Kawaguchi, Makoto, Khanna, Kum Kum, Hida, Hideki, Asai, Kiyofumi, Nishino, Hitoo, Miura, Yutaka
• Format: Journal Article
• Language: English
• Published: England The Company of Biologists Limited 01.12.2005
• Subjects: Active Transport, Cell Nucleus; Animals; Caffeine - pharmacology; Cell Communication; Cell Cycle; Cell Differentiation; Cells, Cultured; Embryo, Mammalian - cytology; Embryonic Development; Exportin 1 Protein; Gene Expression Regulation, Developmental - physiology; Homeodomain Proteins - genetics; Homeodomain Proteins - metabolism; Homeodomain Proteins - physiology; Karyopherins - physiology; Neurons - cytology; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear - physiology

The present study aimed to elucidate the function of AT motif-binding factor 1 (ATBF1) during neurogenesis in the developing brain and in primary cultures of neuroepithelial cells and cell lines (Neuro 2A and P19 cells). Here, we show that ATBF1 is expressed in the differentiating field in associati...