The influence of sodium bromide in man: A study in human volunteers with special emphasis on the endocrine and the central nervous system

• Published in: Food and chemical toxicology Vol. 21; no. 4; pp. 409 - 419
• Main Authors: Sangster, B., Blom, J.L., Sekhuis, V.M., Loeber, J.G., Rauws, A.G., Koedam, J.C., Krajnc, E.I., van Logten, M.J.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.01.1983
• Subjects: Adult; Bromides - administration & dosage; Bromides - blood; Bromides - toxicity; Capsules; Central Nervous System - drug effects; Dose-Response Relationship, Drug; Double-Blind Method; Electroencephalography; Endocrine Glands - drug effects; Evoked Potentials, Visual - drug effects; Female; Hormones - blood; Humans; Male; Menstruation - drug effects; Sodium - administration & dosage; Sodium - toxicity; Sodium Compounds; Time Factors

Sodium bromide was administered orally in capsules to healthy volunteers in doses of 0, 4 or 9 mg Br /kg/day using a double-blind design. Each treatment was given to seven males for 12 weeks and to seven non-pregnant females (not using oral contraceptives) over three full cycles. Special attention w...