Broader anti-EBV TCR repertoire in multiple sclerosis: disease specificity and treatment modulation

• Published in: Brain (London, England : 1878) Vol. 148; no. 3; pp. 933 - 940
• Main Authors: Schneider-Hohendorf, Tilman, Wünsch, Christian, Falk, Simon, Raposo, Catarina, Rubelt, Florian, Mirebrahim, Hamid, Asgharian, Hosseinali, Schlecht, Ulrich, Mattox, Daniel, Zhou, Wenyu, Dawin, Eva, Pawlitzki, Marc, Lauks, Sarah, Jarius, Sven, Wildemann, Brigitte, Havla, Joachim, Kümpfel, Tania, Schrot, Miriam-Carolina, Ringelstein, Marius, Kraemer, Markus, Schwake, Carolin, Schmitter, Thomas, Ayzenberg, Ilya, Fischer, Katinka, Meuth, Sven G, Aktas, Orhan, Hümmert, Martin W, Kretschmer, Julian R, Trebst, Corinna, Kleffner, Ilka, Massey, Jennifer, Muraro, Paolo A, Chen-Harris, Haiyin, Gross, Catharina C, Klotz, Luisa, Wiendl, Heinz, Schwab, Nicholas
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 06.03.2025
• Subjects: Adult; Antibodies, Monoclonal, Humanized - therapeutic use; Epstein-Barr Virus Infections - immunology; Female; Herpesvirus 4, Human - immunology; Humans; Male; Middle Aged; Multiple Sclerosis - immunology; Multiple Sclerosis - therapy; Multiple Sclerosis - virology; Neuromyelitis Optica - immunology; Original; Receptors, Antigen, T-Cell, alpha-beta - immunology; Young Adult; T-cell receptor; Epstein-Barr virus; myelin-oligodendrocyte-glycoprotein antibody-associated disease; multiple sclerosis; neuromyelitis optica spectrum disorder; Susac’s syndrome

Epstein-Barr virus (EBV) infection has long been associated with the development of multiple sclerosis (MS). Patients with MS have elevated titres of EBV-specific antibodies in serum and show signs of CNS damage only after EBV infection. Regarding CD8+ T cells, an elevated but ineffective response t...