Evaluation of variant calling algorithms for wastewater-based epidemiology using mixed populations of SARS-CoV-2 variants in synthetic and wastewater samples

• Published in: Microbial genomics Vol. 9; no. 4
• Main Authors: Bassano, Irene, Ramachandran, Vinoy K., Khalifa, Mohammad S., Lilley, Chris J., Brown, Mathew R., van Aerle, Ronny, Denise, Hubert, Rowe, William, George, Airey, Cairns, Edward, Wierzbicki, Claudia, Pickwell, Natalie D., Carlile, Matthew, Holmes, Nadine, Payne, Alexander, Loose, Matthew, Burke, Terry A., Paterson, Steve, Wade, Matthew J., Grimsley, Jasmine M. S.
• Format: Journal Article
• Language: English
• Published: England Microbiology Society 01.04.2023
• Subjects: Algorithms; COVID-19 - epidemiology; Humans; SARS-CoV-2 - genetics; Wastewater; Wastewater-Based Epidemiological Monitoring; SARS-CoV-2; wastewater; VOC; variant callers; sequencing

Wastewater-based epidemiology has been used extensively throughout the COVID-19 (coronavirus disease 19) pandemic to detect and monitor the spread and prevalence of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) and its variants. It has proven an excellent, complementary tool to clinic...