Sildenafil Prevents Endothelial Dysfunction Induced by Ischemia and Reperfusion via Opening of Adenosine Triphosphate–Sensitive Potassium Channels A Human In Vivo Study

• Published in: Circulation (New York, N.Y.) Vol. 111; no. 6; pp. 742 - 746
• Main Authors: Gori, Tommaso, Sicuro, Silvia, Dragoni, Saverio, Donati, Giovanni, Forconi, Sandro, Parker, John D.
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 15.02.2005
• Subjects: Adult; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Cardiovascular system; Cross-Over Studies; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Double-Blind Method; Drug toxicity and drugs side effects treatment; Endothelium, Vascular - drug effects; Endothelium, Vascular - physiopathology; Glyburide - pharmacology; Humans; Male; Medical sciences; Middle Aged; Myocardial Ischemia - drug therapy; Myocardial Ischemia - metabolism; Myocardial Ischemia - physiopathology; Myocardial Reperfusion Injury - prevention & control; Pharmacology. Drug treatments; Piperazines - administration & dosage; Piperazines - pharmacology; Placebo Effect; Potassium Channels - metabolism; Purines; Sildenafil Citrate; Sulfones; Toxicity: blood; Vasodilator agents. Cerebral vasodilators; Human; endothelium; Purine nucleoside; Adenosine; Vasodilator agent; 3',5'-Cyclic-GMP phosphodiesterase; Enzyme; Enzyme inhibitor; Cardiovascular disease; Esterases; Triphosphates; Phosphoric diester hydrolases; Antiarrhythmic agent; Inorganic element; Ischemia; Hydrolases; Sildenafil; Potassium; reperfusion

Background— Animal studies have demonstrated that administration of sildenafil can limit myocardial damage induced by prolonged ischemia, an effect that appears to be mediated by opening of adenosine triphosphate–sensitive potassium (K ATP ) channels. No study has investigated whether sildenafil can...