Clinical, immunological, anti-inflammatory and antioxidant roles of zinc

• Published in: Experimental gerontology Vol. 43; no. 5; pp. 370 - 377
• Main Author: Prasad, Ananda S.
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.05.2008
• Subjects: Antioxidants - physiology; Cells, Cultured; Elderly; Humans; IL-2; Immunity, Cellular - physiology; Inflammation Mediators - physiology; Interleukins - biosynthesis; Models, Biological; NF-kappa B - metabolism; Phosphorylation; Receptors, Interleukin - metabolism; ROS; TNF-α; Zinc; Zinc - deficiency; Zinc - physiology; IL-2; TNF-α; Elderly; Zinc; ROS

The essentiality of zinc for humans was recognized only 40 years ago. Zinc deficiency was suspected to occur in Iranian patients with growth retardation, hypogonadism in males, hepato-splenomegaly, rough and dry skin, geophagia and severe iron deficiency anemia. Later we documented zinc deficiency i...