Zinc finger genes Fezf1 and Fezf2 control neuronal differentiation by repressing Hes5 expression in the forebrain

• Published in: Development (Cambridge) Vol. 137; no. 11; pp. 1875 - 1885
• Main Authors: Shimizu, Takeshi, Nakazawa, Masato, Kani, Shuichi, Bae, Young-Ki, Shimizu, Takashi, Kageyama, Ryoichiro, Hibi, Masahiko
• Format: Journal Article
• Language: English
• Published: England 01.06.2010
• Subjects: Animals; Base Sequence; Basic Helix-Loop-Helix Transcription Factors - deficiency; Basic Helix-Loop-Helix Transcription Factors - genetics; Cell Differentiation - genetics; Cell Differentiation - physiology; Cell Line; DNA Primers - genetics; DNA-Binding Proteins - deficiency; DNA-Binding Proteins - genetics; Embryonic Stem Cells - cytology; Embryonic Stem Cells - metabolism; Female; Gene Expression Regulation, Developmental; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins - deficiency; Nerve Tissue Proteins - genetics; Neurogenesis - genetics; Neurogenesis - physiology; Neurons - cytology; Neurons - metabolism; Pregnancy; Promoter Regions, Genetic; Prosencephalon - embryology; Prosencephalon - metabolism; Recombinant Proteins - genetics; Repressor Proteins - deficiency; Repressor Proteins - genetics; Telencephalon - embryology; Telencephalon - metabolism; Zinc Fingers - genetics

Precise control of neuronal differentiation is necessary for generation of a variety of neurons in the forebrain. However, little is known about transcriptional cascades, which initiate forebrain neurogenesis. Here we show that zinc finger genes Fezf1 and Fezf2, which encode transcriptional represso...