Positron Emission Tomography Imaging of the Serotonin Transporter and 5-HT1A Receptor in Alcohol Dependence

• Published in: Biological psychiatry (1969) Vol. 65; no. 2; pp. 175 - 180
• Main Authors: Martinez, Diana, Slifstein, Mark, Gil, Roberto, Hwang, Dah-Ren, Huang, Yiyun, Perez, Audrey, Frankle, W. Gordon, Laruelle, Marc, Krystal, John, Abi-Dargham, Anissa
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier 15.01.2009
• Subjects: Addictive behaviors; Adult and adolescent clinical studies; Alcoholism; Alcoholism and acute alcohol poisoning; Biological and medical sciences; Medical sciences; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Toxicology; Alcohol dependence; human subjects; serotonin 1A receptor; serotonin transporter; PET; Radionuclide study; Human; Alcoholism; Serotonine receptor; Alcoholic beverage; 5-HT1A Serotonine receptor; Serotonin transporter; Imaging; Positron emission tomography; Emission tomography

Background Rodent models as well as studies in humans have suggested alterations in serotonin (5-HT) innervation and transmission in early-onset genetically determined or type II alcoholism. This study examines two indices of serotonergic transmission, 5-HT transporter levels and 5-HT1A availability...