Antibody-mediated neuronal apoptosis: Therapeutic implications for prion diseases

• Published in: Immunology Letters Vol. 105; no. 2; pp. 123 - 126
• Main Authors: Tayebi, M., Hawke, S.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.06.2006
• Subjects: Animals; Anti-prion antibody; Antibodies - immunology; Antibodies - pharmacology; Antibodies - therapeutic use; Apoptosis; Apoptosis - drug effects; Humans; Immunotherapy; Neurons - drug effects; Neurons - metabolism; Neurons - pathology; Prion; Prion Diseases - immunology; Prion Diseases - metabolism; Prion Diseases - pathology; Prion Diseases - therapy; Prions - immunology; Prions - metabolism; PrP C; PrP Sc; Anti-prion antibody; Prion; PrP C; PrP Sc; Apoptosis

Neuronal cell death is considered to be a hallmark in prion diseases. These disorders are believed to result from the post-translational conversion of a normal cell membrane sialoglycoprotein PrP C, composed primarily of α-helical structure, into a disease specific isoform, PrP Sc that is rich in β-...