High fat diet induced downregulation of microRNA-467b increased lipoprotein lipase in hepatic steatosis

• Published in: Biochemical and biophysical research communications Vol. 414; no. 4; pp. 664 - 669
• Main Authors: Ahn, Jiyun, Lee, Hyunjung, Chung, Chang Hwa, Ha, Taeyoul
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 04.11.2011
• Subjects: Animals; Diet, High-Fat - adverse effects; Down-Regulation; Fatty liver; Fatty Liver - enzymology; Fatty Liver - genetics; Fatty Liver - pathology; Hepatocytes; High fat diet; Insulin; Insulin resistance; Lipoprotein lipase; Lipoprotein Lipase - antagonists & inhibitors; Lipoprotein Lipase - genetics; Liver diseases; Male; Mice; Mice, Inbred C57BL; MicroRNA-467b; MicroRNAs - genetics; MicroRNAs - metabolism; miRNA; Non-alcoholic fatty liver disease; non-coding RNA; Steatosis; Insulin resistance; MicroRNA-467b; Lipoprotein lipase; Non-alcoholic fatty liver disease; Steatosis

► MicroRNA-467b (miR-467b) is downregulated in high fat diet induced hepatic steatosis. ► Lipoprotein lipase is a direct target of miR-467b. ► MiR-467b – lipoprotein lipase pathway is involved in the insulin resistance of hepatocytes. Non-alcoholic fatty liver disease (NAFLD) is characterized by hep...