Dysregulation of Human Hepatic Drug Transporters by Proinflammatory Cytokines

• Published in: The Journal of pharmacology and experimental therapeutics Vol. 391; no. 1; pp. 82 - 90
• Main Authors: Hao, Tianran, Tsang, Yik Pui, Yin, Mengyue, Mao, Qingcheng, Unadkat, Jashvant D.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.10.2024
• Subjects: Cells, Cultured; Cytokines - metabolism; Hepatocytes - drug effects; Hepatocytes - metabolism; Humans; Liver - drug effects; Liver - metabolism; Membrane Transport Proteins - genetics; Membrane Transport Proteins - metabolism; RNA, Messenger - genetics; RNA, Messenger - metabolism; BCRP; OCT; IFN-γ; IL; OAT; P-gp; TNF-α; NTCP; MRP; OATP; CYP; AUC

Proinflammatory cytokines, elevated during inflammation caused by infection and/or autoimmune disorders, result in reduced clearance of drugs eliminated primarily by cytochrome P450 enzymes (CYPs). However, the effect of cytokines on hepatic drug transporter expression or activity has not been well-...