Minocycline attenuates gentamicin induced hair cell loss in neonatal cochlear cultures

• Published in: Hearing research Vol. 197; no. 1; pp. 11 - 18
• Main Authors: Corbacella, Elisa, Lanzoni, Irene, Ding, Dalian, Previati, Maurizio, Salvi, Richard
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.11.2004; Elsevier
• Subjects: Analysis of Variance; Animals; Animals, Newborn; Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - toxicity; Apoptosis; Apoptosis - drug effects; Biological and medical sciences; Caspase 9; Caspase Inhibitors; Caspases - physiology; Cochlea - drug effects; Cochlea - pathology; Cytochrome c; Cytochromes c - antagonists & inhibitors; Cytochromes c - physiology; Dose-Response Relationship, Drug; Drug toxicity and drugs side effects treatment; Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology; Gentamicin; Gentamicins - toxicity; Hair cells; Hair Cells, Auditory - drug effects; Hearing Loss - chemically induced; Medical sciences; Minocycline; Minocycline - pharmacology; Non tumoral diseases; Organ Culture Techniques; Otorhinolaryngology. Stomatology; Ototoxicity; Pharmacology. Drug treatments; Rats; Toxicity: respiratory system, ent, stomatology; Gentamicin; Hair cells; OHC, outer hair cell; GM, gentamicin; Cytochrome c; iNOS, inducible nitric oxide synthetase; MPTP, mitochondrial permeability transition pore; IHC, inner hair cell; Minocycline; SIMP, soluble intermembrane proteins; MAPK, mitogen-activated protein kinase; Ototoxicity; Apoptosis; Rat; Toxicity; Organotypic culture; Inner ear; Organ of hearing; ENT disease; Bacteria; Enzyme; Internal ear disease; Rodentia; Caspase; Neuroprotective agent; Peptidases; Vertebrata; Antibiotic; Mammalia; Cell death; Aminoglycoside; Animal; Cochlea; Inner hair cell; Hydrolases

Minocycline, a second-generation tetracycline antibiotic used against gram-negative and gram-positive bacteria, protects against a wide range of neurodegenerative disorders by inhibiting caspases, iNOS and the release of cytochrome c. Since aminoglycoside antibiotics damage sensory hair cells in the...