Transcription factors TP53 and SP1 and the osteogenic differentiation of dental stem cells

• Published in: Differentiation (London) Vol. 83; no. 1; pp. 10 - 16
• Main Authors: Oliver, Felthaus, Viale-Bouroncle, Sandra, Driemel, Oliver, Reichert, Torsten E., Schmalz, Gottfried, Morsczeck, Christian
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 2012
• Subjects: apoptosis; binding sites; bone formation; Bone Regeneration; Cell Differentiation - genetics; cell movement; Cell Proliferation; Cells, Cultured; Dental follicle; Dental pulp; Dental Pulp - cytology; Dental Pulp - growth & development; Dental Sac - cytology; Dental Sac - growth & development; Gene expression profiles; Gene Expression Regulation; Gene Silencing; genes; Humans; Immunoglobulins - genetics; Immunoglobulins - metabolism; Osteogenesis - genetics; RNA, Small Interfering - genetics; RNA, Small Interfering - metabolism; small interfering RNA; SP1; stem cells; Stem Cells - cytology; Stem Cells - metabolism; Tissue Engineering; tissue repair; Tooth Exfoliation - genetics; Tooth Exfoliation - metabolism; tooth pulp; TP53; transcription factors; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism; Gene expression profiles; Dental follicle; SP1; TP53; Dental pulp

Dental follicle is a loose connective tissue that surrounds the developing tooth. Dental follicle cells (DFCs) have a promising potential for tissue engineering applications including periodontal and bone regeneration. However, little is known about the molecular mechanisms underlying osteogenic dif...