Cell type‐specific and subcellular expression of phospholipid phosphatase‐related proteins to modulate lyso‐phosphatidic acid synaptic signaling in the developing and adult CNS

• Published in: Journal of neurochemistry Vol. 168; no. 9; pp. 3050 - 3062
• Main Authors: Polyzou, Alexandra, Fuchs, Joachim, Kroon, Cristina, Kotoula, Androniki, Delis, Foteini, Turko, Paul, Antoniou, Katerina, Eickholt, Britta, Leondaritis, George
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.09.2024
• Subjects: Animals; Axon guidance; Axons; bioactive lipid; Brain; Brain - growth & development; Brain - metabolism; Central Nervous System - growth & development; Central Nervous System - metabolism; Cerebellum; Cerebral cortex; Dephosphorylation; Female; Flow cytometry; Fractionation; Gene expression; Gene sequencing; Glutamatergic transmission; Hippocampus; Lysophosphatidic acid; Lysophospholipids - biosynthesis; Lysophospholipids - metabolism; Male; Mice; Mice, Inbred C57BL; Neostriatum; Neurons - metabolism; Neurotransmission; Nuclei (cytology); Nucleus accumbens; Phosphatase; Phosphatidate Phosphatase - biosynthesis; Phosphatidate Phosphatase - genetics; Phosphatidate Phosphatase - metabolism; Phosphatidic acid; Phospholipids; plasticity‐related gene; Prefrontal cortex; PRG; Proteins; Receptor mechanisms; Signal Transduction - physiology; synapse; Synapses; Synapses - metabolism; Synaptic Transmission - physiology; Synaptogenesis; γ-Aminobutyric acid; bioactive lipid; lysophosphatidic acid; synapse; PRG; plasticity‐related gene

Lysophosphatidic acid (LPA) is a bioactive phospholipid that participates in critical processes in neural development and adult brain function and is implicated in various pathophysiological conditions. Along with its six well‐characterized receptors, atypical regulators of LPA signaling have also b...