Motivational Vigor in Parkinson's Disease Requires the Short and Long Duration Response to Levodopa

• Published in: Movement disorders Vol. 39; no. 1; pp. 76 - 84
• Main Authors: Brissenden, James A., Scerbak, Teresa, Albin, Roger L., Lee, Taraz G.
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.01.2024; Wiley Subscription Services, Inc
• Subjects: Aged; Antiparkinson Agents - pharmacology; Antiparkinson Agents - therapeutic use; bradykinesia; dopamine; Dopamine - pharmacology; Female; Humans; Hypokinesia; Levodopa; Levodopa - pharmacology; Levodopa - therapeutic use; l‐dopa; Male; Motivation; Motor task performance; Movement; Movement disorders; Neurodegenerative diseases; Parkinson Disease - drug therapy; Parkinson's disease; Vigor; l-dopa; Parkinson's disease; bradykinesia; dopamine; motivation; vigor

Background Impaired movement vigor (bradykinesia) is a cardinal feature of Parkinson's disease (PD) and hypothesized to result from abnormal motivational processes—impaired motivation‐vigor coupling. Dopamine replacement therapy (DRT) improves bradykinesia, but the response to DRT is multifacet...