The inverse electron demand Diels–Alder cycloaddition with carbon‐11 and fluorine‐18: A gateway to pretargeted imaging across the blood–brain barrier

• Published in: Journal of labelled compounds & radiopharmaceuticals Vol. 66; no. 9; pp. 249 - 268
• Main Authors: Zientek, Simon H., Thompson, Stephen, Sephton, Selena Milicevic, Aigbirhio, Franklin I.
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.07.2023
• Subjects: Antibodies; Biomolecules; Blood-Brain Barrier; Carbon; Carbon cycle; carbon‐11; Cycloaddition; Cycloaddition Reaction; Diels-Alder reactions; Electrons; Fluorine; inverse electron demand Diels‐Alder reaction; Medical imaging; Neuroimaging; Positron emission; Positron emission tomography; pretargeted imaging; Reaction kinetics; tetrazine; trans‐cyclooctene; blood-brain barrier; trans-cyclooctene; carbon-11; inverse electron demand Diels-Alder reaction; tetrazine; pretargeted imaging

There is increased focus on developing tools to image large biomolecules, such as antibodies, within the brain using positron emission tomography (PET). The inverse electron demand Diels–Alder cycloaddition (IEDDA) reaction has offered the greatest prospect of achieving such a feat and has gained mu...