Novel positive allosteric modulator of protease‐activated receptor 1 promotes skin wound healing in hairless mice

• Published in: British journal of pharmacology Vol. 178; no. 17; pp. 3414 - 3427
• Main Authors: Seo, Yohan, Heo, Yunkyung, Jo, Sungwoo, Park, So‐Hyeon, Lee, Chulho, Chang, Jiwon, Jeon, Dong‐Kyu, Kim, Tae Gun, Han, Gyoonhee, Namkung, Wan
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.09.2021
• Subjects: Allosteric properties; Animals; Binding sites; Calcium; Cell migration; Cell viability; Collagen (type I); Fibroblasts; Fibronectin; G protein-coupled receptors; GB83; Gene expression; Hairless; Keratinocytes; Mice; Mice, Hairless; PAR1; positive allosteric modulator; Proteinase; Receptor, PAR-1; Skin; skin wound healing; Thrombin; Thrombosis; Wound Healing; PAR1; skin wound healing; positive allosteric modulator; GB83

Background and Purpose Protease‐activated receptor 1 (PAR1) is a GPCR expressed in several skin cell types, including keratinocyte and dermal fibroblast. PAR1 activation plays a crucial role in the process of skin wound healing such as thrombosis, inflammation, proliferation and tissue repair. In th...