Increased Expression and Modulated Regulatory Activity of Coinhibitory Receptors PD‐1, TIGIT, and TIM‐3 in Lymphocytes From Patients With Systemic Sclerosis

• Published in: Arthritis & rheumatology (Hoboken, N.J.) Vol. 70; no. 4; pp. 566 - 577
• Main Authors: Fleury, Michelle, Belkina, Anna C., Proctor, Elizabeth A., Zammitti, Christopher, Simms, Robert W., Lauffenburger, Douglas A., Snyder‐Cappione, Jennifer E., Lafyatis, Robert, Dooms, Hans
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.04.2018
• Subjects: Adult; Aged; Antibodies; Antibodies, Blocking - metabolism; Apoptosis; Blocking antibodies; Cell activation; Cell death; Cytokines; Cytometry; Exhaustion; Female; Fibroblasts; Fibrosis; Flow cytometry; Gene expression; Hepatitis A Virus Cellular Receptor 2 - blood; Hepatitis A Virus Cellular Receptor 2 - immunology; Humans; Immune system; Immunoglobulins; Leukocytes (mononuclear); Leukocytes, Mononuclear - metabolism; Lymphocytes; Lymphocytes - metabolism; Lymphocytes T; Male; Mathematical models; Middle Aged; Mucin; Natural killer cells; Patients; PD-1 protein; Peripheral blood mononuclear cells; Programmed Cell Death 1 Receptor - blood; Programmed Cell Death 1 Receptor - immunology; Receptor mechanisms; Receptors; Receptors, Immunologic - blood; Receptors, Immunologic - immunology; Scleroderma; Scleroderma, Systemic - blood; Scleroderma, Systemic - immunology; Systemic sclerosis; T cell receptors; T-Lymphocyte Subsets - metabolism

Objective Immune dysfunction is an important component of the disease process underlying systemic sclerosis (SSc), but the mechanisms contributing to altered immune cell function in SSc remain poorly defined. This study was undertaken to measure the expression and function of the coinhibitory recept...