Increased Expression and Modulated Regulatory Activity of Coinhibitory Receptors PD‐1, TIGIT, and TIM‐3 in Lymphocytes From Patients With Systemic Sclerosis - Fleury, Michelle; Belkina, Anna C.; Proctor, Elizabeth A.; Zammitti, Christopher; Simms, Robert W.; Lauffenburger, Douglas A.; Snyder‐Cappione, Jennifer E.; Lafyatis, Robert; Dooms, Hans (Arthritis & rheumatology (Hoboken, N.J.), 2018)
Keywords: Adult; Aged; Antibodies; Antibodies, Blocking - metabolism; Apoptosis; Blocking antibodies; Cell activation; Cell death; Cytokines; Cytometry; Exhaustion; Female; Fibroblasts; Fibrosis; Flow cytometry; Gene expression; Hepatitis A Virus Cellular Receptor 2 - blood; Hepatitis A Virus Cellular Receptor 2 - immunology; Humans; Immune system; Immunoglobulins; Leukocytes (mononuclear); Leukocytes, Mononuclear - metabolism; Lymphocytes; Lymphocytes - metabolism; Lymphocytes T; Male; Mathematical models; Middle Aged; Mucin; Natural killer cells; Patients; PD-1 protein; Peripheral blood mononuclear cells; Programmed Cell Death 1 Receptor - blood; Programmed Cell Death 1 Receptor - immunology; Receptor mechanisms; Receptors; Receptors, Immunologic - blood; Receptors, Immunologic - immunology; Scleroderma; Scleroderma, Systemic - blood; Scleroderma, Systemic - immunology; Systemic sclerosis; T cell receptors; T-Lymphocyte Subsets - metabolism