Randomised clinical trial: faecal microbiota transplantation for recurrent Clostridum difficile infection – fresh, or frozen, or lyophilised microbiota from a small pool of healthy donors delivered by colonoscopy

• Published in: Alimentary pharmacology & therapeutics Vol. 45; no. 7; pp. 899 - 908
• Main Authors: Jiang, Z. D., Ajami, N. J., Petrosino, J. F., Jun, G., Hanis, C. L., Shah, M., Hochman, L., Ankoma‐Sey, V., DuPont, A. W., Wong, M. C., Alexander, A., Ke, S., DuPont, H. L.
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.04.2017
• Subjects: Adult; Aged; Aged, 80 and over; Antibiotics; Bacteria; Clinical trials; Clostridium difficile; Clostridium Infections - therapy; Colon; Colonoscopy; Donors; Double-Blind Method; Fecal Microbiota Transplantation; Feces - microbiology; Female; Freeze Drying; Freezing; Humans; Male; Microbiota; Microbiota - genetics; Middle Aged; Randomization; Recurrence; Recurrent infection; RNA, Ribosomal, 16S - genetics; rRNA 16S; Specimen Handling; Tissue Donors; Transplantation; Young Adult

Summary Background Faecal microbiota transplantation (FMT) has become routine in managing recurrent C. difficile infection (CDI) refractory to antibiotics. Aim To compare clinical response and improvements in colonic microbiota diversity in subjects with recurrent CDI using different donor product....