Insulinoma‐associated 1: A novel nuclear marker in Merkel cell carcinoma (cutaneous neuroendocrine carcinoma)
Merkel cell carcinoma (MCC) is a rare, clinically aggressive, cutaneous neuroendocrine (NE) neoplasm. As a tumor with small, round, blue cells, the histologic differential diagnosis for MCC can include melanoma, metastatic small cell carcinoma (SCC), nodular hematopoietic tumors, basal cell carcinom...
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| Published in | Journal of cutaneous pathology Vol. 45; no. 2; pp. 129 - 135 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford, UK
Blackwell Publishing Ltd
01.02.2018
Wiley Subscription Services, Inc |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Merkel cell carcinoma (MCC) is a rare, clinically aggressive, cutaneous neuroendocrine (NE) neoplasm. As a tumor with small, round, blue cells, the histologic differential diagnosis for MCC can include melanoma, metastatic small cell carcinoma (SCC), nodular hematopoietic tumors, basal cell carcinoma (BCC), atypical variants of squamous carcinoma and the uncommon occurrence of primary cutaneous Ewing sarcoma. In cases with atypical histology or without the classic immunophenotype, the diagnosis can be challenging. Ultimately, immunohistochemistry (IHC) is essential to the definitive diagnosis of MCC and in difficult cases, the diagnosis may hinge entirely on the immunophenotype of the tumor cells. Insulinoma‐associated 1 (INSM1) is a transcription factor expressed in tissues undergoing terminal NE differentiation. As a nuclear protein tied to both differentiation and the cell cycle, INSM1 may offer additional utility in comparison to traditional, cytoplasmic markers of NE differentiation. |
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| AbstractList | Merkel cell carcinoma (MCC) is a rare, clinically aggressive, cutaneous neuroendocrine (NE) neoplasm. As a tumor with small, round, blue cells, the histologic differential diagnosis for MCC can include melanoma, metastatic small cell carcinoma (SCC), nodular hematopoietic tumors, basal cell carcinoma (BCC), atypical variants of squamous carcinoma and the uncommon occurrence of primary cutaneous Ewing sarcoma. In cases with atypical histology or without the classic immunophenotype, the diagnosis can be challenging. Ultimately, immunohistochemistry (IHC) is essential to the definitive diagnosis of MCC and in difficult cases, the diagnosis may hinge entirely on the immunophenotype of the tumor cells. Insulinoma‐associated 1 (INSM1) is a transcription factor expressed in tissues undergoing terminal NE differentiation. As a nuclear protein tied to both differentiation and the cell cycle, INSM1 may offer additional utility in comparison to traditional, cytoplasmic markers of NE differentiation. |
| Author | Rush, Patrick S. Roy, Madhuchhanda Baus, Rebecca M. Rosenbaum, Jason N. Bennett, Daniel D. Lloyd, Ricardo V. |
| Author_xml | – sequence: 1 givenname: Patrick S. orcidid: 0000-0001-6572-1325 surname: Rush fullname: Rush, Patrick S. email: patrick.s.rush@gmail.com, prush@mgh.harvard.edu organization: University of Wisconsin Hospital and Clinics – sequence: 2 givenname: Jason N. orcidid: 0000-0002-7969-7423 surname: Rosenbaum fullname: Rosenbaum, Jason N. organization: University of Pennsylvania – sequence: 3 givenname: Madhuchhanda surname: Roy fullname: Roy, Madhuchhanda organization: University of Wisconsin Hospital and Clinics – sequence: 4 givenname: Rebecca M. surname: Baus fullname: Baus, Rebecca M. organization: University of Wisconsin Hospital and Clinics – sequence: 5 givenname: Daniel D. surname: Bennett fullname: Bennett, Daniel D. organization: University of Wisconsin Hospital and Clinics – sequence: 6 givenname: Ricardo V. surname: Lloyd fullname: Lloyd, Ricardo V. organization: University of Wisconsin Hospital and Clinics |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29148079$$D View this record in MEDLINE/PubMed |
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| Keywords | immunoperoxidase neuroendocrine INSM1 carcinoma cutaneous neuroendocrine Merkel cell |
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| SubjectTerms | Basal cell carcinoma carcinoma Cell cycle cutaneous neuroendocrine Differential diagnosis Ewing's sarcoma Immunohistochemistry immunoperoxidase INSM1 Insulinoma Melanoma Merkel cell Metastases Neoplasia neuroendocrine Neuroendocrine tumors Tumor cells Tumors |
| Title | Insulinoma‐associated 1: A novel nuclear marker in Merkel cell carcinoma (cutaneous neuroendocrine carcinoma) |
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