Variants in TNFAIP3, STAT4, and C12orf30 loci associated with multiple autoimmune diseases are also associated with juvenile idiopathic arthritis

• Published in: Arthritis and rheumatism Vol. 60; no. 7; pp. 2124 - 2130
• Main Authors: Prahalad, Sampath, Hansen, Sterling, Whiting, April, Guthery, Stephen L., Clifford, Bronte, McNally, Bernadette, Zeft, Andrew S., Bohnsack, John F., Jorde, Lynn B.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.07.2009; Wiley
• Subjects: Adult; Arthritis - genetics; Arthritis, Juvenile - genetics; Arthritis, Rheumatoid - genetics; Autoimmune Diseases - genetics; Biological and medical sciences; Case-Control Studies; Child; Child, Preschool; Diseases of the osteoarticular system; DNA-Binding Proteins; Female; Genetic Predisposition to Disease - genetics; Humans; Inflammatory joint diseases; Interleukin-2 Receptor alpha Subunit - genetics; Intracellular Signaling Peptides and Proteins - genetics; Lupus Erythematosus, Systemic - genetics; Male; Medical sciences; N-Terminal Acetyltransferase B; Nuclear Proteins - genetics; Polymorphism, Single Nucleotide - genetics; Proteins - genetics; STAT4 Transcription Factor - genetics; TNF Receptor-Associated Factor 1 - genetics; Tumor Necrosis Factor alpha-Induced Protein 3; Immunopathology; Chronic; Multiple; Diseases of the osteoarticular system; Rheumatology; Juvenile rheumatoid arthritis; Autoimmune disease; Inflammatory joint disease

Objective Subtypes of juvenile idiopathic arthritis (JIA) share phenotypic features with other autoimmune disorders. We investigated several genetic variants associated with rheumatoid arthritis (RA) and other autoimmune disorders for association with JIA to test the hypothesis that clinically disti...