Combination of chemically modified SDF‐1α mRNA and small skin improves wound healing in diabetic rats with full‐thickness skin defects

• Published in: Cell proliferation Vol. 55; no. 12; pp. e13318 - n/a
• Main Authors: Luo, Zucheng, Bian, Yujie, Zheng, Rui, Song, Yonghuan, Shi, Li, Xu, Haiting, Wang, Huijing, Li, Xiaoyan, Tao, Zhenyu, Wang, Anyuan, Liu, Ke, Fu, Wei, Xue, Jixin
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.12.2022
• Subjects: Angiogenesis; Animals; Chemokine CXCL12 - genetics; Chemokine CXCL12 - pharmacology; Chemokines; Cytokines; Defects; Diabetes; Diabetes mellitus; Diabetes Mellitus, Experimental - pathology; Diabetes Mellitus, Experimental - therapy; Diabetic retinopathy; Evaluation; Fluorescence; Fluorescence microscopy; In vitro methods and tests; mRNA; Neovascularization, Physiologic; Plastic surgery; Public health; Rats; RNA polymerase; RNA, Messenger - genetics; Skin & tissue grafts; Skin - pathology; Skin diseases; Skin lesions; Thickness; Transfection; Transplantation; Wound Healing

Objectives Diabetes mellitus is associated with refractory wound healing, yet current therapies are insufficient to accelerate the process of healing. Recent studies have indicated chemically modified mRNA (modRNA) as a promising therapeutic intervention. The present study aimed to explore the effic...