Role of CaMKII and sarcolipin in muscle adaptations to strength training with different levels of fatigue in the set

• Published in: Scandinavian journal of medicine & science in sports Vol. 31; no. 1; pp. 91 - 103
• Main Authors: Martinez‐Canton, Miriam, Gallego‐Selles, Angel, Gelabert‐Rebato, Miriam, Martin‐Rincon, Marcos, Pareja‐Blanco, Fernando, Rodriguez‐Rosell, David, Morales‐Alamo, David, Sanchis‐Moysi, Joaquin, Dorado, Cecilia, Jose Gonzalez‐Badillo, Juan, Calbet, Jose A. L.
• Format: Journal Article
• Language: English
• Published: Denmark Blackwell Publishing Ltd 01.01.2021
• Subjects: Adaptation, Physiological; Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism; exercise; fatigue; human; Humans; Male; Mitochondria, Muscle - metabolism; Mitochondrial Proteins - biosynthesis; Muscle Fatigue; Muscle Proteins - metabolism; Muscle, Skeletal - metabolism; myosin heavy chain; Myosin Heavy Chains - metabolism; Phosphorylation; Proteolipids - metabolism; Resistance Training - methods; skeletal muscle; Skeletal Muscle Enlargement; Sports training; Strength training; velocity‐based training; myosin heavy chain; exercise; fatigue; skeletal muscle; velocity-based training; human
• ISSN: 0905-7188; 1600-0838; 1600-0838
• DOI: 10.1111/sms.13828

Strength training promotes a IIX‐to‐IIA shift in myosin heavy chain (MHC) composition, likely due to changes in sarcoplasmic [Ca2+] which are sensed by CaMKII. Sarcoplasmic [Ca2+] is in part regulated by sarcolipin (SLN), a small protein that when overexpressed in rodents stimulates mitochondrial bi...