In vivo activity of the dual PI3Kδ and PI3Kγ inhibitor duvelisib against pediatric acute lymphoblastic leukemia xenografts - Randall, Joanna; Evans, Kathryn; Watts, Ben; Smith, Christopher M.; Hughes, Keira; Earley, Eric J.; Erickson, Stephen W.; Pachter, Jonathan A.; Teicher, Beverly A.; Smith, Malcolm A.; Lock, Richard B. (Pediatric blood & cancer, 2023)
Keywords: 1-Phosphatidylinositol 3-kinase; Acute lymphoblastic leukemia; Animals; CD45 antigen; Child; Chronic lymphocytic leukemia; Drug efficacy; duvelisib; Gene expression; Hematology; Heterografts; Humans; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy; Lymphatic leukemia; Lymphoma; Lymphoma, B-Cell - pathology; Malignancy; Mice; Mice, Inbred NOD; Morbidity; Oncology; patient‐derived xenografts; pediatric acute lymphoblastic leukemia; Pediatrics; Peripheral blood; Phosphatidylinositol 3-Kinases; PI3K; preclinical drug testing; Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy; Xenografts; preclinical drug testing; PI3K; pediatric acute lymphoblastic leukemia; duvelisib; patient-derived xenografts