Vastly accelerated linear least‐squares fitting with numerical optimization for dual‐input delay‐compensated quantitative liver perfusion mapping

• Published in: Magnetic resonance in medicine Vol. 79; no. 4; pp. 2415 - 2421
• Main Authors: Jafari, Ramin, Chhabra, Shalini, Prince, Martin R., Wang, Yi, Spincemaille, Pascal
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.04.2018
• Subjects: bolus arrival time; Computer simulation; Delay; dynamic contrast‐enhanced MRI; Frames per second; hepatic lesion perfusion analysis; Least squares; linear and nonlinear least squares fitting; linear inversion; Liver; Magnetic resonance; Mathematical models; Perfusion; Temporal resolution; bolus arrival time; linear inversion; linear and nonlinear least squares fitting; dynamic contrast-enhanced MRI; hepatic lesion perfusion analysis

Purpose To propose an efficient algorithm to perform dual input compartment modeling for generating perfusion maps in the liver. Methods We implemented whole field‐of‐view linear least squares (LLS) to fit a delay‐compensated dual‐input single‐compartment model to very high temporal resolution (four...