Down‐regulation of microRNA‐34c‐5p alleviates neuropathic pain via the SIRT1/STAT3 signaling pathway in rat models of chronic constriction injury of sciatic nerve

• Published in: Journal of neurochemistry Vol. 154; no. 3; pp. 301 - 315
• Main Authors: Mo, Yanshuai, Liu, Benjuan, Qiu, Shuang, Wang, Xueqin, Zhong, Lina, Han, Xiao, Mi, Fuli
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.08.2020
• Subjects: Animal models; Animals; Chromosome 5; chronic constriction injury; Constriction, Pathologic; Constrictions; Cords; Deactivation; Disease Models, Animal; Dorsal root ganglia; Down-Regulation; Ectopic expression; Gene Expression Regulation - genetics; Inactivation; Inflammation; inflammatory factors; Kinases; Latency; Lipopolysaccharides; Male; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; microRNA‐34c‐5p; miRNA; Neuralgia; Neuralgia - genetics; Neuralgia - metabolism; neuropathic pain; Pain; Pain perception; Public health; Quality of life; Rats; Rats, Sprague-Dawley; Ribonucleic acid; RNA; Sciatic nerve; Sciatic Nerve - injuries; Signal transduction; Signal Transduction - physiology; Signaling; SIRT1; SIRT1 protein; Sirtuin 1 - genetics; Sirtuin 1 - metabolism; Stat3 protein; STAT3 signaling pathway; STAT3 Transcription Factor - genetics; STAT3 Transcription Factor - metabolism; Tumor necrosis factor; chronic constriction injury; microRNA-34c-5p; neuropathic pain; STAT3 signaling pathway; SIRT1; inflammatory factors

Neuropathic pain is an unfavorable pathological pain, often persistent over time, thus leading to significant impairment of quality of life and public health burden. Notably, microRNAs have been implicated in the pathophysiological process of neuropathic pain. The potential mechanism by which miR‐34...