Down‐regulation of microRNA‐34c‐5p alleviates neuropathic pain via the SIRT1/STAT3 signaling pathway in rat models of chronic constriction injury of sciatic nerve - Mo, Yanshuai; Liu, Benjuan; Qiu, Shuang; Wang, Xueqin; Zhong, Lina; Han, Xiao; Mi, Fuli (Journal of neurochemistry, 2020)
Keywords: Animal models; Animals; Chromosome 5; chronic constriction injury; Constriction, Pathologic; Constrictions; Cords; Deactivation; Disease Models, Animal; Dorsal root ganglia; Down-Regulation; Ectopic expression; Gene Expression Regulation - genetics; Inactivation; Inflammation; inflammatory factors; Kinases; Latency; Lipopolysaccharides; Male; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; microRNA‐34c‐5p; miRNA; Neuralgia; Neuralgia - genetics; Neuralgia - metabolism; neuropathic pain; Pain; Pain perception; Public health; Quality of life; Rats; Rats, Sprague-Dawley; Ribonucleic acid; RNA; Sciatic nerve; Sciatic Nerve - injuries; Signal transduction; Signal Transduction - physiology; Signaling; SIRT1; SIRT1 protein; Sirtuin 1 - genetics; Sirtuin 1 - metabolism; Stat3 protein; STAT3 signaling pathway; STAT3 Transcription Factor - genetics; STAT3 Transcription Factor - metabolism; Tumor necrosis factor; chronic constriction injury; microRNA-34c-5p; neuropathic pain; STAT3 signaling pathway; SIRT1; inflammatory factors