Bacterial Butyrate in Parkinson's Disease Is Linked to Epigenetic Changes and Depressive Symptoms

• Published in: Movement disorders Vol. 37; no. 8; pp. 1644 - 1653
• Main Authors: Xie, Aoji, Ensink, Elizabeth, Li, Peipei, Gordevičius, Juozas, Marshall, Lee L., George, Sonia, Pospisilik, John Andrew, Aho, Velma T.E., Houser, Madelyn C., Pereira, Pedro A.B., Rudi, Knut, Paulin, Lars, Tansey, Malú G., Auvinen, Petri, Brundin, Patrik, Brundin, Lena, Labrie, Viviane, Scheperjans, Filip
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.08.2022; Wiley Subscription Services, Inc
• Subjects: Bisulfite; Butyrates; Depression - genetics; Digestive system; DNA methylation; Epidemiology; Epigenesis, Genetic; Epigenetics; Feces; Gastrointestinal Microbiome - genetics; Gastrointestinal tract; Genomes; Gut-brain axis; Humans; Intestinal microflora; Leukocytes (neutrophilic); Mental depression; Mental disorders; Metabolites; microbiome; Microbiomes; Microbiota; Movement disorders; Neurodegenerative diseases; Neurons; Parkinson Disease - complications; Parkinson Disease - genetics; Parkinson Disease - microbiology; Parkinson's disease; Patients; Prefrontal cortex; DNA methylation; Parkinson's disease; gut brain axis; microbiome; epigenetics

Background The gut microbiome and its metabolites can impact brain health and are altered in Parkinson's disease (PD) patients. It has been recently demonstrated that PD patients have reduced fecal levels of the potent epigenetic modulator butyrate and its bacterial producers. Objectives Here,...