Sera with anti‐enteric neuronal antibodies from patients with irritable bowel syndrome promote apoptosis in myenteric neurons of guinea pigs and human SH‐Sy5Y cells

• Published in: Neurogastroenterology and motility Vol. 30; no. 12; pp. e13457 - n/a
• Main Authors: Fan, Wenjuan, Fei, Guijun, Li, Xiaoqing, Wang, Xiyu, Hu, Chaojun, Xin, Haiwei, Sun, Xiaohong, Li, Yongzhe, Wood, Jackie D, Fang, Xiucai
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.12.2018
• Subjects: Antibodies; Apoptosis; autoantibodies; Autoimmune diseases; Caspase; Constipation; Degeneration; Enteric nervous system; Fetal calf serum; Flow cytometry; Fluorescence; Immunofluorescence; Immunoglobulins; Inflammatory bowel diseases; Irritable bowel syndrome; Myenteric plexus; Neurons; Neuropathy; Small intestine; apoptosis; enteric nervous system; irritable bowel syndrome; autoantibodies

Background Sera anti‐enteric neuronal antibodies (AENA), neuronal inflammation, and degeneration in myenteric plexus in patients with irritable bowel syndrome (IBS) were reported. Effects of sera AENA in patients with IBS are unclear. Methods Patients with IBS met Rome III criteria were enrolled. Co...