Inhibition of PIKFYVE kinase interferes ESCRT pathway to suppress RNA virus replication

• Published in: Journal of medical virology Vol. 95; no. 2; pp. e28527 - n/a
• Main Authors: Luo, Zhen, Liang, Yicong, Tian, Mingfu, Ruan, Zhihui, Su, Rui, Shereen, Muhammad Adnan, Yin, Jialing, Wu, Kailang, Guo, Jun, Zhang, Qiwei, Li, Yongkui, Wu, Jianguo
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.02.2023
• Subjects: Antiviral agents; Antiviral drugs; antiviral therapy; DNA viruses; endosomal sorting complex required for transport (ESCRT); Endosomal Sorting Complexes Required for Transport - genetics; Endosomal Sorting Complexes Required for Transport - metabolism; Enteroviruses; enveloped RNA viruses; Hepatitis B; Humans; Infections; Inflammation; Interferon; Kinases; nonenveloped RNA viruses; Phosphatidylinositol 3-Kinases; phosphoinositide kinase FYVE finger containing (PIKFYVE); Poliovirus - genetics; Replication; Ribonucleic acid; RNA; RNA virus replication; RNA viruses; Stomatitis; Vector-borne diseases; Virology; Virus Replication - physiology; Viruses; Zika virus; Zika Virus - genetics; Zika Virus Infection; phosphoinositide kinase FYVE finger containing (PIKFYVE); RNA virus replication; enveloped RNA viruses; antiviral therapy; nonenveloped RNA viruses; endosomal sorting complex required for transport (ESCRT)

Endosomal sorting complex required for transport (ESCRT) is essential in the functional operation of endosomal transport in envelopment and budding of enveloped RNA viruses. However, in nonenveloped RNA viruses such as enteroviruses of the Picornaviridae family, the precise function of ESCRT pathway...