Metabolic syndrome, its components, and gastrointestinal cancer risk: a meta‐analysis of 31 prospective cohorts and Mendelian randomization study

• Published in: Journal of gastroenterology and hepatology Vol. 39; no. 4; pp. 630 - 641
• Main Authors: Zhan, Zhi‐Qing, Chen, Ying‐Zhou, Huang, Ze‐Min, Luo, Yu‐Hua, Zeng, Jia‐Jian, Wang, Ye, Tan, Juan, Chen, Ying‐Xuan, Fang, Jing‐Yuan
• Format: Journal Article
• Language: English
• Published: Australia Wiley Subscription Services, Inc 01.04.2024
• Subjects: Cancer; Cancer prevention; Children; Cholesterol; Cohort analysis; Cohort Studies; Colorectal carcinoma; Female; Gallbladder cancer; Gastric cancer; Gastrointestinal cancers; Gastrointestinal Neoplasms - epidemiology; Gastrointestinal Neoplasms - etiology; Gastrointestinal Neoplasms - genetics; High density lipoprotein; Humans; Hyperglycemia; Hypertriglyceridemia; Liver cancer; Male; Mendelian Randomization Analysis; Meta-analysis; Metabolic syndrome; Metabolic Syndrome - epidemiology; Metabolic Syndrome - genetics; Minority & ethnic groups; Obesity; Obesity - complications; Pancreatic cancer; Prospective Studies; Risk; Risk factor; Risk Factors; Sensitivity analysis; Cancer prevention; Gastrointestinal cancers; Metabolic syndrome; Risk factor

Background and Aim Cohort studies have linked metabolic syndrome (MetS) to gastrointestinal (GI) cancer risk. We aimed to evaluate the associations between MetS, its components, and combinations of MetS components with eight GI cancers risk. Methods We conducted a systematic search of prospective co...