Genomic data in prognostic models—what is lost in translation? The case of deletion 17p and mutant TP53 in chronic lymphocytic leukaemia

• Published in: British journal of haematology Vol. 188; no. 5; pp. 652 - 660
• Main Authors: Chin‐Yee, Benjamin, Sadikovic, Bekim, Chin‐Yee, Ian H.
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.03.2020
• Subjects: Chromosome 17; Chromosome deletion; chronic lymphocytic leukaemia; Chronic lymphocytic leukemia; Copy number; Cytogenetics; Gene deletion; Genetic screening; Genomics; Hematology; Leukemia; Mutants; Mutation; next‐generation sequencing; Oncology; p53 Protein; Prognosis; prognostic models; prognostic models; genomics; chronic lymphocytic leukaemia; cytogenetics; next-generation sequencing

Summary Genomic technologies are revolutionizing the practice of haematology‐oncology, leading to improved disease detection, more accurate prognostication and targeted treatment decisions. These advances, however, have also introduced new clinical challenges, which include problems of prognostic un...