Amentoflavone attenuates Listeria monocytogenes pathogenicity through an LLO‐dependent mechanism

• Published in: British journal of pharmacology Vol. 179; no. 14; pp. 3839 - 3858
• Main Authors: Tingting, Wang, Tianqi, Fang, Xinyu, Wang, Can, Zhang, Xue, Shen, Xuming, Deng, Jianfeng, Wang
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.07.2022
• Subjects: amentoflavone; barrier function; Calcium efflux; Calcium influx; Cell injury; Cytotoxicity; Herbal medicine; Immune response; Infections; Inflammation; Listeria monocytogenes; Listeriolysin O; listeriolysin O (LLO) inhibitor; Pathogenicity; Surface plasmon resonance; Therapeutic targets; Virulence; amentoflavone; Listeria monocytogenes; listeriolysin O (LLO) inhibitor; immune response; barrier function

Background and Purpose L. monocytogenes remain a leading cause of foodborne infection. Listeriolysin O (LLO), an indispensable virulence determinant involved in diverse pathogenic mechanisms of L. monocytogenes infection, represents a promising therapeutic target. In this study, we sought to identif...