Patients with chronic prostatitis/chronic pelvic pain syndrome show T helper type 1 (Th1) and Th17 self‐reactive immune responses specific to prostate and seminal antigens and diminished semen quality

• Published in: BJU international Vol. 126; no. 3; pp. 379 - 387
• Main Authors: Motrich, Ruben D., Breser, María L., Molina, Rosa I., Tissera, Andrea, Olmedo, José J., Rivero, Virginia E.
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.09.2020
• Subjects: Acid phosphatase; Adult; Antigens; Apoptosis; Autoantibodies; Autoantigens - immunology; autoimmunity; CD4 antigen; Cell Proliferation; Chronic pain; Genital tract; Helper cells; Humans; Immune response; Immunoglobulin G; Inflammation; Leukocytes (mononuclear); Leukocytes, Mononuclear - cytology; Leukocytes, Mononuclear - immunology; Lymphocytes; Lymphocytes T; Macrophages; Male; MaleInfertility; Middle Aged; Necrosis; Pain; Peripheral blood mononuclear cells; Prospective Studies; Prostate; Prostate - immunology; Prostatitis; Prostatitis - blood; Prostatitis - immunology; Prostatitis - physiopathology; Quality; Semen; Semen - immunology; Semen Analysis; Sperm; Th1 Cells - immunology; Th17 Cells - immunology; γ-Interferon; MaleInfertility; autoimmunity; prostatitis; inflammation; semen analysis
• ISSN: 1464-4096; 1464-410X; 1464-410X
• DOI: 10.1111/bju.15117

Objectives To assess the presence of self‐reactive immune responses to seminal and prostate antigens (PAg), biomarkers of inflammation of the male genital tract, and semen quality parameters in patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). Patients, Subjects and Methods P...