Synthetic lethal targeting of TET2‐mutant haematopoietic stem and progenitor cells by XPO1 inhibitors - Jing, Chang‐Bin; Prutsch, Nicole; He, Shuning; Zimmerman, Mark W.; Landesman, Yosef; Look, A. Thomas (British journal of haematology, 2023)
Keywords: Acute myeloid leukemia; Animals; Apoptosis; Ataxin; Cell death; clonal haematopoiesis; Dioxygenases - metabolism; DNA damage; DNA-Binding Proteins - genetics; eltanexor; Embryos; Exportin 1 Protein; Genetic transformation; Hematology; Hematopoietic Stem Cells - metabolism; Hemopoiesis; HSPC; Humans; Leukemia, Myeloid, Acute - drug therapy; Leukemia, Myeloid, Acute - genetics; Leukemia, Myeloid, Acute - pathology; Malignancy; Mice; Mutants; Progenitor cells; selinexor; TET2; XPO1; Zebrafish; TET2; XPO1; eltanexor; selinexor; clonal haematopoiesis; HSPC